Cabergoline

Cat. No. 2664

Cabergoline C26H37N5O2 [81409-90-7]

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Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide

Biological Activity

Selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Technical Data

M.Wt:
451.6
Formula:
C26H37N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
81409-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin.Ther. 28 1065. PMID: 16982285.

Hadj Tahar et al (2000) Sustained cabergoline treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195.

Eguchi et al (1995) Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413. PMID: 7670571.

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Keywords: Cabergoline, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products

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