Cat. No. 2664
Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(eth
Biological ActivitySelective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin.Ther. 28 1065. PMID: 16982285.
Hadj Tahar et al (2000) Sustained cabergoline treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195.
Eguchi et al (1995) Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413. PMID: 7670571.
If you know of a relevant reference for Cabergoline please let us know.
Citations are publications that use Tocris products. Selected citations for Cabergoline include:
Lin et al (2015) Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline. PLoS One 6 39329. PMID: 26513171.
Odaka et al (2014) Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. J Biol Chem 9 e99271. PMID: 24914776.
Do you know of a great paper that uses Cabergoline from Tocris? If so please let us know.
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Keywords: Cabergoline, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products