2-Chloro-N6-cyclopentyladenosine

Cat. No. 1705

2-Chloro-N6-cyclopentyladenosine C15H20ClN5O4 [37739-05-2]

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Alternative Name: CCPA

Chemical Name: 2-Chloro-N-cyclopentyladenosine

Biological Activity

Potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
369.81
Formula:
C15H20ClN5O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
37739-05-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382. PMID: 11111832.

Monopoli et al (1994) Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44 1305. PMID: 7848348.

Concas et al (1993) Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J.Pharmacol.Exp.Ther. 267 844. PMID: 8246158.

Lohse et al (1988) 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 337 687. PMID: 3216901.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 2-Chloro-N6-cyclopentyladenosine include:

Goldman et al (2013) Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. BMC Pharmacol Toxicol 53 297. PMID: 23462235.

Wu et al (2013) Opiate-induced changes in brain adenosine levels and narcotic drug responses. J Neurosci 228 235. PMID: 23098802.

Crawford et al (2012) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. Cell Calcium 32 13100. PMID: 22993427.

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Neuroscience 32 14489. PMID: 23077035.

Ru et al (2011) Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol 300 G485. PMID: 21148396.

Keene et al (2010) Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol 80 188. PMID: 20346920.

Long et al (2010) Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Neurosci 335 781. PMID: 20855445.

Do you know of a great paper that uses 2-Chloro-N6-cyclopentyladenosine from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 2-Chloro-N6-cyclopentyladenosine, supplier, Potent, selective, A1, agonists, Receptors, adenosines, Tocris Bioscience, Adenosine A1 Receptor Agonist products

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