Cat. No. 1702
Alternative Name: CPA
Chemical Name: N-Cyclopentyladenosine
Biological ActivityPotent and selective adenosine A1 receptor agonist (Ki values are 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively; EC50 = 18600 nM for hA2B). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382. PMID: 11111832.
Van der Graaf et al (1997) Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors. J.Pharmacol.Exp.Ther. 283 809. PMID: 9353402.
Coffin and Spealman (1987) Behavioral and cardiovascular effects of analogs of adenosine in Cynomolgus monkeys. J.Pharmacol.Exp.Ther. 241 76. PMID: 3572798.
If you know of a relevant reference for N6-Cyclopentyladenosine please let us know.
Citations are publications that use Tocris products. Selected citations for N6-Cyclopentyladenosine include:
Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. PMID: 27577957.
Kavanagh et al (2015) Role of adenosine receptor subtypes in methamphetamine reward and reinforcement. PLoS One 89 265. PMID: 25301277.
Nguyen et al (2014) Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex. PLoS One 9 e87165. PMID: 24494035.
Kozma et al (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol 85 1171. PMID: 23376019.
Lemieux et al (2012) Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses. J Cell Biol 198 1055. PMID: 22965911.
Jensen et al (2007) Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3. Neuropharmacology 579 85. PMID: 17170045.
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Keywords: N6-Cyclopentyladenosine, supplier, Potent, selective, A1, agonists, Receptors, adenosines, Tocris Bioscience, Adenosine A1 Receptor Agonist products
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