A 77636 hydrochloride

Cat. No. 1701

A 77636 hydrochloride C20H27NO3.HCl [145307-34-2]

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Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride

Biological Activity

Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.

Technical Data

M.Wt:
365.9
Formula:
C20H27NO3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
145307-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lewis et al (1998) Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther. 286 345. PMID: 9655879.

Acquas et al (1994) The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol. 260 85. PMID: 7957630.

Kebabian et al (1992) A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol. 229 203. PMID: 1362704.

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Citations are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823. PMID: 22639870.

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