CGS 15943

Cat. No. 1699

CGS 15943 C13H8ClN5O [104615-18-1]

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Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Biological Activity

Potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Orally active in vivo.

Technical Data

M.Wt:
285.69
Formula:
C13H8ClN5O
Solubility:
Soluble to 5 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
104615-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382. PMID: 11111832.

Ghai et al (1987) Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 242 784. PMID: 3656113.

Williams et al (1987) Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 241 415. PMID: 2883298.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGS 15943 include:

Avanzato et al (2016) Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling Scientific Reports 6 32602. PMID: 27586846.

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.

Do you know of a great paper that uses CGS 15943 from Tocris? If so please let us know.

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Keywords: CGS 15943, supplier, Potent, adenosines, receptor, antagonists, Non-Selective, Receptors, CGS15943, Tocris Bioscience, Non-selective Adenosine Antagonist products

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