L-655,240

Cat. No. 1698

L-655,240 C21H21ClFNO2 [103253-15-2]

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Chemical Name: 1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid

Biological Activity

Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo.

Technical Data

M.Wt:
373.85
Formula:
C21H21ClFNO2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
103253-15-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789. PMID: 1531361.

Wainright and Parratt (1988) The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J.Cardiovasc.Pharmacol. 12 264. PMID: 2464097.

Hall et al (1987) Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist. Eur.J.Pharmacol. 135 193. PMID: 3582493.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L-655,240 include:

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228. PMID: 19096033.

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Keywords: L-655,240, supplier, Potent, selective, thromboxane, A2, endoperoxide, TP, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L655240, Tocris Bioscience, Prostanoid Receptor Antagonist products

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