Cat. No. 1695

Cisapride C23H29ClFN3O4 [81098-60-4]

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Alternative Name: R 51619

Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide

Biological Activity

5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Briejer et al (1993) Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 347 464. PMID: 8321323.

Taniyama et al (1991) Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 258 1098. PMID: 1890614.

Schuurkes et al (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 234 775. PMID: 3897516.

If you know of a relevant reference for Cisapride please let us know.

Citations are publications that use Tocris products. Selected citations for Cisapride include:

Padayatti et al (2013) A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics 12 1259. PMID: 23378516.

Do you know of a great paper that uses Cisapride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Cisapride, supplier, 5-HT4, agonists, stimulates, Serotonin, Receptors, 5-Hydroxytryptamine, stimulate, ACh, acetylcholine, release, nicotinic, muscarinic, nAChR, R51619, Tocris Bioscience, 5-HT4 Receptor Agonist products

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