Cat. No. 1694
Alternative Name: KC-404
Chemical Name: 2-Methyl-1-[2-(1-methylethyl)pyrazo
Biological ActivityPhosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kishi et al (2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 19 215. PMID: 11607039.
Souness et al (1994) Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 111 1081. PMID: 8032594.
Nishino et al (1983) KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 33 267. PMID: 6193303.
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Keywords: Ibudilast, supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, KC404, Tocris Bioscience, Phosphodiesterase Inhibitor products
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