Enoximone

Cat. No. 1693

Enoximone C12H12N2O2S [77671-31-9]

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Chemical Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one

Biological Activity

Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Technical Data

M.Wt:
248.3
Formula:
C12H12N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
77671-31-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, on myocyte calcium cycling and contractility. J.Pharmacol.Exp.Ther. 312 517. PMID: 15550574.

Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263. PMID: 10935673.

Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122. PMID: 8672353.

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Keywords: Enoximone, supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Tocris Bioscience, Phosphodiesterase Inhibitor products

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