NECA

Cat. No. 1691

NECA C12H16N6O4 [35920-39-9]

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Alternative Name: 5'-N-Ethylcarboxamidoadenosine

Chemical Name: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

Biological Activity

High affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.

Technical Data

M.Wt:
308.3
Formula:
C12H16N6O4
Solubility:
Soluble to 40 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
35920-39-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Knapp et al (2001) Adenosine agonists CGS21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol.Biochem.Behav. 68 797. PMID: 11526979.

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382. PMID: 11111832.

Cusack and Hourani (1981) 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation. Br.J.Pharmacol. 72 443. PMID: 7260485.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NECA include:

Poddar et al (2014) Enhanced brain distribution of modified aspartoacylase. Mol Genet Metab 113 219. PMID: 25066302.

Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond) 11 37. PMID: 25473378.

Bulavina et al (2013) NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal 9 199. PMID: 23208703.

Kinsey et al (2012) Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. J Am Soc Nephrol 23 1528. PMID: 22835488.

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7. PMID: 20085655.

Jin et al (2010) CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res 70 2245. PMID: 20179192.

Clark et al (2009) Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci 29 11237. PMID: 19741130.

Xi et al (2009) Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol 47 684. PMID: 19695259.

Do you know of a great paper that uses NECA from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: NECA, supplier, adenosines, receptor, agonists, Non-Selective, Receptors, 5-N-Ethylcarboxamidoadenosine, Tocris Bioscience, Non-selective Adenosine Agonist products

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