Autocamtide-2-related inhibitory peptide

Cat. No. 1688

Autocamtide-2-related inhibitory peptide Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

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Alternative Name: AIP

Biological Activity

Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

Technical Data

M.Wt:
1497.76
Formula:
C64H116N22O19
Sequence:
KKALRRQEAVDAL
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
167114-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806. PMID: 7626114.

Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163. PMID: 7836445.

Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257. PMID: 8530441.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:

Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165. PMID: 23055486.

Do you know of a great paper that uses Autocamtide-2-related inhibitory peptide from Tocris? If so please let us know.

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Keywords: Autocamtide-2-related inhibitory peptide, supplier, Selective, CaM, kinase, II, inhibitors, inhibits, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, Tocris Bioscience, Calcium Binding Protein Modulator Inhibitor products

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