VDM 11 (in Tocrisolve™ 100)
Cat. No. 1686
Chemical Name: (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-meth
Biological ActivityA potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisoveTM 100, Cat. No. 1684). IC50 values for inhibition of AMT are 4 - 11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5 - 10 mM at CB1 and CB2. Active in vivo. VDM 11 also available (pure oil dissolved in ethanol, Cat. No. 1392).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Gubellini et al (2002) Experimental Parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. J.Neurosci. 22 6900. PMID: 12177188.
Bisogno et al (2001) The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur.J.Biochem. 268 1982. PMID: 11277920.
De Petrocellis et al (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J.Biol.Chem. 276 12856. PMID: 11278420.
De Petrocellis et al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52. PMID: 11033355.
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Keywords: VDM 11 (in Tocrisolve 100), supplier, Potent, selective, anandamide, transporters, inhibitors, inhibits, water-soluble, emulsion, AMT, Anandamide, cannabinoids, Monoamine, Neurotransmitter, VDM11, Tocrisolve100, Tocris Bioscience, Cannabinoid Transporter Inhibitor products
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