Cat. No. 1684
Biological ActivityWater soluble emulsion composed of a 1:4 ratio of soya oil/water that is emulsified with the block co-polymer Pluronic F68. Can be diluted with any aqueous medium. Used to solubilize hydrophobic organic chemicals and water-insoluble lipids such as cannabinoids and vanilloids. The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water. Also can be used as a negative control for reagents in TocrisolveTM 100; Anandamide, AM 404, VDM 11, ACPA, (R)-(+)-Methanandamide, JWH 133 and Arachidonic acid (Cat. Nos. 1017, 1685, 1686, 1781, 1782, 1783 and 2756 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Oltmanns et al (2008) Topical WIN55212-2 alleviates intraocular hypertenision in rats through a CB1 receptor mediated mechanism of action. J.Ocul.Pharmacol.Ther. 24 104. PMID: 18201139.
Hosseini et al (2006) Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp.Eye Res. 82 753. PMID: 16289049.
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Citations are publications that use Tocris products. Selected citations for Tocrisolve™ 100 include:
Fraga-Silva et al (2013) Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. Clin Dev Immunol 2013 263846. PMID: 24302957.
Li et al (2013) Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide. Am J Physiol Regul Integr Comp Physiol 305 R404. PMID: 23785073.
Wyeth et al (2010) Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci 30 8993. PMID: 20592220.
Brozoski et al (2009) Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Auton Neurosci 150 82. PMID: 19464961.
Mendiguren and Pineda (2009) Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices. Br J Pharmacol 158 1579. PMID: 19845674.
Tjen-A-Looi et al (2009) Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. J Appl Physiol (1985) 106 1793. PMID: 19325030.
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272. PMID: 17592514.
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Keywords: Tocrisolve 100, supplier, Water-soluble, emulsion, negative, control, 7, 1685, 1686, 1781, 1782, 1783, 2756, Tocrisolve100, Tocris Bioscience, Other Cannabinoid products
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