Cat. No. 1684
Biological ActivityWater soluble emulsion composed of a 1:4 ratio of soya oil/water that is emulsified with the block co-polymer Pluronic F68. Can be diluted with any aqueous medium. Used to solubilize hydrophobic organic chemicals and water-insoluble lipids such as cannabinoids and vanilloids. The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water. Also can be used as a negative control for reagents in TocrisolveTM 100; Anandamide, AM 404, VDM 11, ACPA, (R)-(+)-Methanandamide, JWH 133 and Arachidonic acid (Cat. Nos. 1017, 1685, 1686, 1781, 1782, 1783 and 2756 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Oltmanns et al (2008) Topical WIN55212-2 alleviates intraocular hypertenision in rats through a CB1 receptor mediated mechanism of action. J.Ocul.Pharmacol.Ther. 24 104. PMID: 18201139.
Hosseini et al (2006) Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp.Eye Res. 82 753. PMID: 16289049.
If you know of a relevant reference for Tocrisolve™ 100 please let us know.
Citations are publications that use Tocris products. Selected citations for Tocrisolve™ 100 include:
Hwang et al (2015) Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. J Neuroinflammation 38 843. PMID: 26434492.
Nishikawa et al (2015) Cytoprotective Effects of Lysophospholipids from Sea Cucumber Holothuria atra. Br J Pharmacol 10 e0135701. PMID: 26275144.
Amenta et al (2014) Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury. PLoS One 11 191. PMID: 25416141.
Toguri et al (2014) Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. Behav Brain Res 171 1448. PMID: 24308861.
Fraga-Silva et al (2013) Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. Clin Dev Immunol 2013 263846. PMID: 24302957.
Li et al (2013) Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide. Am J Physiol Regul Integr Comp Physiol 305 R404. PMID: 23785073.
Enman and Unterwald (2012) Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse. J Neurosci 231 217. PMID: 22649795.
Montecucco et al (2012) The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. Br J Pharmacol 33 846. PMID: 22112961.
Ho et al (2010) Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. Br J Pharmacol 160 736. PMID: 20590576.
Wyeth et al (2010) Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci 30 8993. PMID: 20592220.
Brozoski et al (2009) Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Auton Neurosci 150 82. PMID: 19464961.
Mendiguren and Pineda (2009) Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices. Br J Pharmacol 158 1579. PMID: 19845674.
Tjen-A-Looi et al (2009) Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. J Appl Physiol (1985) 106 1793. PMID: 19325030.
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272. PMID: 17592514.
Gaskari et al (2005) Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Eur Heart J 146 315. PMID: 16025138.
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Keywords: Tocrisolve 100, supplier, Water-soluble, emulsion, negative, control, 7, 1685, 1686, 1781, 1782, 1783, 2756, Tocrisolve100, Tocris Bioscience, Other Cannabinoid products
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