NSC 632839 hydrochloride

Cat. No. 2647

NSC 632839 hydrochloride C21H21NO.HCl [157654-67-6]

Price and Availability

For NSC 632839 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: F6

Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

Technical Data

M.Wt:
339.86
Formula:
C21H21NO.HCl
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
157654-67-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235. PMID: 16982768.

If you know of a relevant reference for NSC 632839 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364. PMID: 27098497.

Do you know of a great paper that uses NSC 632839 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: NSC 632839 hydrochloride, supplier, inhibitors, inhibits, ubiquitin, isopeptidase, activity, Proteases, Proteinases, NSC632839, hydrochloride, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

SB 3CT

Selective high affinity MMP2 inhibitor

(R)-MG 132

Potent 20S proteasome inhibitor

Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Experimental Biology 2017

Experimental Biology 2017

April 22 - 26, 2017

Chicago, IL, USA

Booth: 1341