NSC 632839 hydrochloride

Cat. No. 2647

NSC 632839 hydrochloride C21H21NO.HCl [157654-67-6]

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Alternative Name: F6

Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

Technical Data

M.Wt:
339.86
Formula:
C21H21NO.HCl
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
157654-67-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235. PMID: 16982768.

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Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364. PMID: 27098497.

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Keywords: NSC 632839 hydrochloride, supplier, inhibitors, inhibits, ubiquitin, isopeptidase, activity, Proteases, Proteinases, NSC632839, hydrochloride, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

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