NSC 632839 hydrochloride
Cat. No. 2647
Alternative Name: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-
Biological ActivityInhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235. PMID: 16982768.
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Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364. PMID: 27098497.
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Keywords: NSC 632839 hydrochloride, supplier, inhibitors, inhibits, ubiquitin, isopeptidase, activity, Proteases, Proteinases, NSC632839, hydrochloride, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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