(±)-Blebbistatin

Cat. No. 1760

()-Blebbistatin C18H16N2O2 [674289-55-5]

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Chemical Name: (±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

Biological Activity

Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Technical Data

M.Wt:
292.34
Formula:
C18H16N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
674289-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Walker et al (2010) Non-muscle myosin II regulates survival threshold of pluripotent stem cells. Nat.Commun. 1 71. PMID: 20842192.

Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337. PMID: 15548862.

Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743. PMID: 12637748.

Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (±)-Blebbistatin include:

Gao et al (2016) MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. Nat Commun 6 25120. PMID: 27112594.

Chang et al (2015) Role of sarcoplasmic reticulum calcium in development of secondary calcium rise and early afterdepolarizations in long QT syndrome rabbit model. J Cell Sci 10 e0123868. PMID: 25875599.

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. Int J Nanomedicine 6 6364. PMID: 25695512.

Chazeau et al (2015) Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines. Int J Cancer 26 859. PMID: 25568337.

Choi et al (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. J Cell Biol 136 E219. PMID: 25137150.

Jesus et al (2015) Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation. Mol Biol Cell 12 169. PMID: 25304682.

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. PLoS One 160 673. PMID: 25679761.

Tai et al (2015) Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation. Heart Rhythm 10 5881. PMID: 26451103.

Talele et al (2015) Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells. Stem Cell Reports 4 1016. PMID: 26028530.

Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Cell 208 821. PMID: 25753039.

Zangle et al (2014) Live Cell Interferometry Quantifies Dynamics of Biomass Partitioning during Cytokinesis. PLoS One 9 e115726. PMID: 25531652.

Glukhov et al (2013) Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Circ Arrhythm Electrophysiol 6 984. PMID: 23960214.

Haan et al (2013) Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy. PLoS One 8 e59290. PMID: 23516623.

Liu et al (2013) Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. J Mol Cell Cardiol 54 25. PMID: 23123323.

Burkel et al (2012) A Rho GTPase signal treadmill backs a contractile array. Dev Cell 23 384. PMID: 22819338.

Chu et al (2012) Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway. J Signal Transduct 2012 473410. PMID: 22900166.

Seese et al (2012) LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice. J Neurosci 32 7403. PMID: 22623686.

Fedorov et al (2011) Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. J Mol Cell Cardiol 51 215. PMID: 21586291.

Kaur et al (2011) RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers. Arterioscler Thromb Vasc Biol 31 657. PMID: 21148427.

Lang et al (2011) Optical mapping of action potentials and calcium transients in the mouse heart. J Vis Exp. PMID: 21946907.

Lang et al (2011) Role of Pyk2 in cardiac arrhythmogenesis. J Inflamm (Lond) 301 H975. PMID: 21666110.

Lou et al (2011) Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure. Circulation 123 1881. PMID: 21502574.

Matsubayashi et al (2011) 'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion. Proc Natl Acad Sci U S A 124 1017. PMID: 21402875.

Ruiz and Chen (2008) Emergence of patterned stem cell differentiation within multicellular structures. Sci Rep 26 2921. PMID: 18703661.

Charras et al (2006) Reassembly of contractile actin cortex in cell blebs. J Cell Biol 175 477. PMID: 17088428.

Vidali et al (2006) Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell 17 2377. PMID: 16525021.

Nelson et al (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Am J Physiol Heart Circ Physiol 102 11594. PMID: 16049098.

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Keywords: ()-Blebbistatin, supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, activity, P-Type, V-Type, E-Type, F-Type, ATPases, GTPases, Myosin, Tocris Bioscience, Myosin Inhibitor products

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