T 0156 hydrochloride

Cat. No. 1676

T 0156 hydrochloride C31H29N5O7.HCl [324572-93-2]

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Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

Biological Activity

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Technical Data

Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283. PMID: 14757152.

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91. PMID: 12450574.

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Citations are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:

Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977. PMID: 25404319.

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Keywords: T 0156 hydrochloride, supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, Tocris Bioscience, Phosphodiesterase Inhibitor products

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