T 0156 hydrochloride

Cat. No. 1676

T 0156 hydrochloride C31H29N5O7.HCl [324572-93-2]

Price and Availability

For T 0156 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

Biological Activity

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Technical Data

M.Wt:
620.06
Formula:
C31H29N5O7.HCl
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
324572-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283. PMID: 14757152.

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91. PMID: 12450574.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses T 0156 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: T 0156 hydrochloride, supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, Tocris Bioscience, Phosphodiesterase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

New Products in this Area

Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

pCPA methyl ester hydrochloride

Tryptophan hydroxylase inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.