YM 90709

Cat. No. 1675

YM 90709 C22H21N3O2 [163769-88-8]

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Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline

Biological Activity

Novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data

M.Wt:
359.43
Formula:
C22H21N3O2
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
163769-88-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Morokata et al (2005) Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol.Lett. 98 161. PMID: 15790522.

Morokata et al (2004) Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 4 873. PMID: 15182727.

Morokata et al (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2 1693. PMID: 12469943.

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Keywords: YM 90709, supplier, Interleukin-5, receptor, inhibitors, inhibits, antagonists, IL, receptors, interleukins, cytokines, YM90709, IL-5, inhibitor, Tocris Bioscience, Cytokine Receptor Antagonist products

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