Cl-HIBO

Cat. No. 1673

Cl-HIBO C6H7ClN2O4 [909400-43-7]

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Alternative Name: 4-Chlorohomoibotenic acid

Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid

Biological Activity

Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).

Technical Data

M.Wt:
206.59
Formula:
C6H7ClN2O4
Solubility:
Soluble to 20 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
909400-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bjerrum et al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246. PMID: 12747796.

Kristensen et al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7.

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Keywords: Cl-HIBO, supplier, Subtype-selective, AMPA, agonists, GluR1, GluR2, Glutamate, Receptors, iGluR, Ionotropic, Chloro-homoibotenic, acid, Tocris Bioscience, AMPA Receptor Agonist products

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