RU 28318, potassium salt
Cat. No. 1672
Alternative Name: Oxprenoate potassium
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpre
Biological ActivityPotent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876.
Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980.
Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881.
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Citations are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:
Sabourin et al (2016) Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes. J.Biol.Chem. 291 13394. PMID: 27129253.
Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870. PMID: 22948976.
Luther et al (2011) Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia 54 2152. PMID: 21519965.
Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183. PMID: 18772142.
Crochemore et al (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. J Neurosci 10 790. PMID: 15940303.
Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. Proc Natl Acad Sci U S A 25 4288. PMID: 15858055.
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Keywords: RU 28318, potassium salt, supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt, Tocris Bioscience, Mineralocorticoid Receptor Antagonist products
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