RU 28318, potassium salt

Cat. No. 1672

RU 28318, potassium salt C25H37O4K [76676-34-1]

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Alternative Name: Oxprenoate potassium

Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt

Biological Activity

Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.

Technical Data

M.Wt:
440.66
Formula:
C25H37O4K
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
76676-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876.

Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980.

Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881.

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Citations are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:

Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870. PMID: 22948976.

Luther et al (2011) Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia 54 2152. PMID: 21519965.

Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183. PMID: 18772142.

Do you know of a great paper that uses RU 28318, potassium salt from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: RU 28318, potassium salt, supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt, Tocris Bioscience, Mineralocorticoid Receptor Antagonist products

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