PD 102807

Cat. No. 1671

PD 102807 C23H24N2O4 [23062-91-1]

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Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester

Biological Activity

Selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bohme et al (2002) Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors. J.Med.Chem. 45 3094. PMID: 12086495.

Kitaichi et al (1999) A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type. Eur.J.Pharmacol. 383 53. PMID: 10556681.

Augelli-Szafran et al (1998) Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 8 1991. PMID: 9873472.

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Citations are publications that use Tocris products.

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Keywords: PD 102807, supplier, Selective, M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, PD102807, Tocris Bioscience, M4 Receptor Antagonist products

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