Cat. No. 1671
Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-m
Biological ActivitySelective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bohme et al (2002) Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors. J.Med.Chem. 45 3094. PMID: 12086495.
Kitaichi et al (1999) A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type. Eur.J.Pharmacol. 383 53. PMID: 10556681.
Augelli-Szafran et al (1998) Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 8 1991. PMID: 9873472.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PD 102807 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PD 102807, supplier, Selective, M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, PD102807, Tocris Bioscience, M4 Receptor Antagonist products