GW 1929 hydrochloride

Cat. No. 1664

GW 1929 hydrochloride C30H29N3O4.HCl [1217466-21-1]

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Chemical Name: N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride

Biological Activity

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
532.03
Formula:
C30H29N3O4.HCl
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
1217466-21-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729. PMID: 11579205.

Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651. PMID: 11373275.

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415. PMID: 10389847.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GW 1929 hydrochloride include:

Chai et al (2013) Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS One 8 e62934. PMID: 23658787.

Hatano et al (2010) Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators. Endocrinology 125 160. PMID: 19818482.

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