Cat. No. 1657
Alternative Name: BN 52021
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,1
Biological ActivityPlatelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235. PMID: 12169298.
Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412. PMID: 2825685.
Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83. PMID: 3019727.
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Keywords: Ginkgolide B, supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, Tocris Bioscience, Platelet-Activating Factor (PAF) Receptor Antagonist products
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