A 350619 hydrochloride

Cat. No. 2753

A 350619 hydrochloride C21H25ClN2OS.HCl [1217201-17-6]

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Chemical Name: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride

Biological Activity

Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.

Technical Data

Soluble to 100 mM in water
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Kotzki et al (2013) Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J.Pharmacol.Exp.Ther. 346 424. PMID: 23838678.

Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755. PMID: 16955067.

Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015. PMID: 12495780.

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