Cat. No. 1646
Alternative Name: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-i
Biological ActivityAnticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928. PMID: 12411425.
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411. PMID: 7833093.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15. PMID: 6717891.
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61. PMID: 6793318.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Lonidamine from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Lonidamine, supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, Tocris Bioscience, Hexokinases Inhibitor products
Find multiple products by catalog number
New Products in this Area
MSK/RSK family kinase inhibitorLTURM 34
Potent DNA-PK inhibitorMLi-2
Potent and selective LRRK2 inhibitorLTURM 36
PI 3-kinase δ inhibitorPI 3065
Potent and selective PI 3-kinase p110δ inhibitorAZ PFKFB3 67
Potent and selective PFKFB3 inhibitorSTOCK2S 26016
Lysine deficient protein kinase (WNK) signaling inhibitorrac-CCT 250863
Potent Nek2 inhibitorRoscovitine
Potent, selective cyclin-dependent kinase inhibitorEnzastaurin
Potent PKCβ inhibitorBMS 265246
Potent cdk1/2 inhibitorAutocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptideMP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeableAkti-1/2
Potent and selective dual Akt1 and 2 inhibitor
December 3 - 7, 2016
San Francisco, CA,