8-CPT-2Me-cAMP, sodium salt
Cat. No. 1645
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methylad
Biological ActivitySelective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.
Licensing InformationSold with the permission of BioLog Life Science Institute
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279. PMID: 12496249.
Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901. PMID: 12402047.
Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275. PMID: 9856955.
If you know of a relevant reference for 8-CPT-2Me-cAMP, sodium salt please let us know.
Citations are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:
Hutchison and White (2015) Prostacyclin regulates bone growth via the Epac/Rap1 pathway. PLoS One 156 499. PMID: 25406016.
Mohan et al (2015) Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Endocrinology 46 53. PMID: 25451967.
Garcia-Murillas et al (2014) An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene 33 2478. PMID: 23752180.
Guichard et al (2013) Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 14 294. PMID: 24034615.
Hu et al (2012) Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109 17681. PMID: 23045693.
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.
Soltoff and Hedden (2010) Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem 285 13337. PMID: 20207737.
Jeong et al (2007) IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 282 20752. PMID: 17517894.
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Keywords: 8-CPT-2Me-cAMP, sodium salt, supplier, Selective, Epacs, epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase, Tocris Bioscience, GTPase Activator products
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