Cat. No. 1644
Alternative Name: CU-32-085
Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N
Biological Activity5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Marko (1984) Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 101 263. PMID: 6468500.
Markstei (1983) Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 95 101. PMID: 6230246.
If you know of a relevant reference for Mesulergine hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:
Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Neurotoxicology 9 e0004063. PMID: 26367744.
Do you know of a great paper that uses Mesulergine hydrochloride from Tocris? If so please let us know.
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Keywords: Mesulergine hydrochloride, supplier, 5-HT2A, 5-HT2C, 5-HT, serotonin, antagonists, D2, dopamine, partial, agonists, antiprolactin, antiParkinsonian, Tocris Bioscience, 5-HT2A Receptor Antagonist products
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