D-64131

Cat. No. 1643

D-64131 C16H13NO2
 [74588-78-6]

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Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone

Biological Activity

Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.

Technical Data

M.Wt:
251.28
Formula:
C16H13NO2
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
74588-78-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113. PMID: 12036922.

Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535. PMID: 11741473.

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Keywords: D-64131, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, Tocris Bioscience, Microtubule products

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