Cat. No. 1643
Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmeth
Biological ActivityNovel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113. PMID: 12036922.
Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535. PMID: 11741473.
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Keywords: D-64131, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, Tocris Bioscience, Microtubule products