Urotensin II (human)

Cat. No. 1642

Urotensin II (human) Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: 5 - 10)

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Biological Activity

Potent endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.

Technical Data

M.Wt:
1388.57
Formula:
C64H85N13O18S2
Sequence:
ETPDCFWKYCV

(Modifications: Disulfide bridge between 5 - 10)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
251293-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Maguire and Davenport (2002) Is urotensin-II the new endothelin? Br.J.Pharmacol 137 579. PMID: 12381671.

Nothacker et al (1999) Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1 383. PMID: 10559967.

Coulouarn et al (1998) Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 95 15803. PMID: 9861051.

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Keywords: Urotensin II (human), supplier, Endogenous, vasoactive, agonists, UT, receptor, Receptors, Urotensin-II, UrotensinII, (human), Tocris Bioscience, Urotensin-II Receptor Agonist products

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

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