Urotensin II (human)
Cat. No. 1642
Biological ActivityPotent endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.
(Modifications: Disulfide bridge between 5 - 10)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Maguire and Davenport (2002) Is urotensin-II the new endothelin? Br.J.Pharmacol 137 579. PMID: 12381671.
Nothacker et al (1999) Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1 383. PMID: 10559967.
Coulouarn et al (1998) Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 95 15803. PMID: 9861051.
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Keywords: Urotensin II (human), supplier, Endogenous, vasoactive, agonists, UT, receptor, Receptors, Urotensin-II, UrotensinII, (human), Tocris Bioscience, Urotensin-II Receptor Agonist products
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