Probucol

Cat. No. 2775

Probucol C31H48O2S2 [23288-49-5]

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Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]

Biological Activity

Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

Technical Data

M.Wt:
516.84
Formula:
C31H48O2S2
Solubility:
Soluble to 25 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
23288-49-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477. PMID: 17293560.

Ruixing et al (2006) Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549. PMID: 17101546.

Ku et al (1990) Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties. FASEB J. 4 1645. PMID: 2318380.

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Keywords: Probucol, supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, Tocris Bioscience, Antioxidant products

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