Cat. No. 1638
Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]andro
Biological ActivityInhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Incardona et al (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 224 440. PMID: 10926779.
Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796. PMID: 2745416.
Cenedella et al (1980) Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 29 2751. PMID: 6159896.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses U 18666A from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: U 18666A, supplier, inhibitors, hedgehog, Hh, signaling, inhibits, cholesterol, synthesis, Signalling, Hedgehog, U18666A, Tocris Bioscience, Hedgehog Signaling Inhibitor products
Find multiple products by catalog number
New Products in this Area
Hedgehog signaling activator; brain penetrant and orally bioavailableG10
Activator of STING-dependent signaling3',3'-cGAMP sodium salt
STING agonist2',3'-cGAMP sodium salt
Endogenous high affinity STING agonist
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands