U 18666A

Cat. No. 1638

U 18666A C25H41NO2.HCl [3039-71-2]

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Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

Biological Activity

Inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Incardona et al (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 224 440. PMID: 10926779.

Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796. PMID: 2745416.

Cenedella et al (1980) Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 29 2751. PMID: 6159896.

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Citations are publications that use Tocris products.

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Keywords: U 18666A, supplier, inhibitors, hedgehog, Hh, signaling, inhibits, cholesterol, synthesis, Signalling, Hedgehog, U18666A, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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