Argatroban

Cat. No. 1637

Argatroban C23H36N6O5S [74863-84-6]

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Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid

Biological Activity

Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

Technical Data

M.Wt:
508.63
Formula:
C23H36N6O5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
74863-84-6

Resources

Other Information

  • This compound is a mixture of 2 diastereomers (approximate ratio 65/35)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jang et al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219. PMID: 2297828.

Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 86 7585.

Kikumoto et al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85. PMID: 6691968.

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Keywords: Argatroban, supplier, Potent, inhibitors, thrombin, fibrinogen, inhibits, antithrombitic, Tocris Bioscience, Other Protease Inhibitor products

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