Concanamycin A

Cat. No. 2656

Concanamycin A C46H75NO14 [80890-47-7]

Price and Availability

For Concanamycin A pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Folimycin

Chemical Name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

Biological Activity

Specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Technical Data

M.Wt:
866.09
Formula:
C46H75NO14
Solubility:
Soluble in DMSO
Purity:
>90 %
Storage:
Store at -20°C
CAS No:
80890-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hong et al (2006) Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 319 672. PMID: 16895977.

Nishihara et al (1995) Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm. 212 255.

Muroi et al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18 139.

If you know of a relevant reference for Concanamycin A please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Concanamycin A from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Concanamycin A, supplier, H+-ATPase, vacuolar, inhibitors, inhibits, V-Type, Hydrogen-ATPases, Ion, Transporters, Pumps, ConcanamycinA, antibiotics, Tocris Bioscience, H+-ATPase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

NMS 873

Potent and selective p97 ATPase (VCP) allosteric inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

SENC 2017

17th National Congress of the Spanish Society of Neuroscience

September 27 - 30, 2017

Alicante, Spain