Y-29794 oxalate

Cat. No. 1634

Y-29794 oxalate C23H34N2OS2.C2H2O4 [146794-84-5]

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Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone oxalate

Biological Activity

Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.

Technical Data

Soluble to 15 mM in ethanol with gentle warming and to 15 mM in DMSO
>96 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kato et al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328. PMID: 9336340.

Nakajima et al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156. PMID: 1436628.

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Keywords: Y-29794 oxalate, supplier, Prolyl, endopeptidase, inhibitors, inhibits, prolyl, prevents, amyloid, β-peptide, beta-peptide-like, deposition, vivo, Proteases, Proteinases, Beta, Amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, amyloidbeta, amyloidb, Tocris Bioscience, Other Protease Inhibitor products

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