Cat. No. 1634
Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6
Biological ActivityInhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kato et al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328. PMID: 9336340.
Nakajima et al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156. PMID: 1436628.
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Keywords: Y-29794 oxalate, supplier, Prolyl, endopeptidase, inhibitors, inhibits, prolyl, prevents, amyloid, β-peptide, beta-peptide-like, deposition, vivo, Proteases, Proteinases, Beta, Amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, amyloidbeta, amyloidb, Tocris Bioscience, Other Protease Inhibitor products
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