MEN 10376

Cat. No. 1632

MEN 10376 Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2

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Biological Activity

Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.

Technical Data

M.Wt:
1081.24
Formula:
C57H68N12O10
Sequence:
DYWVWWK

(Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
135306-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512. PMID: 8185607.

Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805. PMID: 1380373.

Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172. PMID: 1710662.

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Keywords: MEN 10376, supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10376, Tocris Bioscience, Neurokinin (NK2) Receptor Antagonist products

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