Cat. No. 3002
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3
Biological ActivityAntioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Takuma et al (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 406 333. PMID: 11040339.
Civenni et al (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 370 161. PMID: 10323265.
Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 11 177. PMID: 15374467.
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Citations are publications that use Tocris products.
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Keywords: Idebenone, supplier, Antioxidant, neuroprotective, agent, Tocris Bioscience, Antioxidant products
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