Herbimycin A

Cat. No. 1629

Herbimycin A C30H42N2O9 [70563-58-5]

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Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin

Biological Activity

Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Technical Data

M.Wt:
574.67
Formula:
C30H42N2O9
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
70563-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244. PMID: 16218955.

McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987. PMID: 15051479.

Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155. PMID: 8131836.

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Keywords: Herbimycin A, supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Tocris Bioscience, Src Kinase Inhibitor products

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