Cat. No. 1625
Alternative Name: 3,3'-Difluorobenzaldazine
Chemical Name: [(3-Fluorophenyl)methylene]hydrazon
Biological ActivityNovel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2 - 5.3 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zhang et al (2005) Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 315 1212. PMID: 16135701.
O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731. PMID: 12920211.
Williams et al (2002) DFB, an allosteric potentiator of mGluR5 4th International Meeting on Metabotropic Glutamat.
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Keywords: DFB, supplier, Allosteric, potentiators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products