Bryostatin 1

Cat. No. 2383

Bryostatin 1 C47H68O17 [83314-01-6]

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Alternative Name: NSC 339555

Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester

Biological Activity

Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data

M.Wt:
905.04
Formula:
C47H68O17
Solubility:
Soluble in DMSO and in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
83314-01-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393. PMID: 24659806.

Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1. PMID: 16834754.

Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624. PMID: 9618462.

Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338. PMID: 9407126.

If you know of a relevant reference for Bryostatin 1 please let us know.

Citations are publications that use Tocris products. Selected citations for Bryostatin 1 include:

Lin et al (2016) Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis PLoS One 11 e0164164. PMID: 27701470.

Do you know of a great paper that uses Bryostatin 1 from Tocris? If so please let us know.

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Keywords: Bryostatin 1, supplier, Protein, kinases, C, activators, PKC, Bryostatin1, NSC339555, Tocris Bioscience, Protein Kinase C Activator products

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