2-Methylthioadenosine diphosphate trisodium salt

Cat. No. 1624

2-Methylthioadenosine diphosphate trisodium salt C11H14N5Na3O10P2S [475193-31-8]

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Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Biological Activity

Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

Soluble in water (supplied pre-dissolved at a concentration of 10mM)
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131. PMID: 11747319.

Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705. PMID: 11961076.

Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420. PMID: 6298277.

If you know of a relevant reference for 2-Methylthioadenosine diphosphate trisodium salt please let us know.

Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

Voss et al (2014) The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Br J Pharmacol 10 455. PMID: 24510452.

Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119. PMID: 24784220.

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050. PMID: 24048730.

Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Nature 5 ra26. PMID: 22472648.

Yamanaka et al (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One 7 e45032. PMID: 23056190.

Ohtani et al (2008) Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets. Purinergic Signal 4 365. PMID: 18784987.

Do you know of a great paper that uses 2-Methylthioadenosine diphosphate trisodium salt from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 2-Methylthioadenosine diphosphate trisodium salt, supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products

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