Remacemide hydrochloride

Cat. No. 1622

Remacemide hydrochloride C17H20N2O.HCl [111686-79-4]

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Alternative Name: FPL 12924AA

Chemical Name: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride

Biological Activity

Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
304.82
Formula:
C17H20N2O.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
111686-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Santangeli et al (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 438 63. PMID: 11906711.

Subramaniam et al (1996) Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 276 161. PMID: 8558426.

Palmer et al (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 765 236. PMID: 7486610.

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Keywords: Remacemide hydrochloride, supplier, NMDA, antagonists, blocks, ion, channel, allosteric, modulatory, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, AstraZeneca, Tocris Bioscience, NMDA Receptor Antagonist products

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