SN 38

Cat. No. 2684

SN 38 C22H20N2O5 [86639-52-3]

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Alternative Name: 7-Ethyl-10-hydroxycamptothecin

Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

Biological Activity

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Technical Data

M.Wt:
392.4
Formula:
C22H20N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
86639-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Koizumi et al (2006) Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res. 66 10048. PMID: 17047068.

Gao et al (2005) Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 15 3233. PMID: 15913996.

Kawato et al (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 51 4187. PMID: 1651156.

If you know of a relevant reference for SN 38 please let us know.

Citations are publications that use Tocris products. Selected citations for SN 38 include:

Jonchère et al (2015) Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. Oncotarget 6 409. PMID: 25565667.

Vétillard et al (2015) Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Exp Neurol 6 43342. PMID: 26485768.

Do you know of a great paper that uses SN 38 from Tocris? If so please let us know.

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Keywords: SN 38, supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, SN38, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products

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