Cat. No. 2733
Chemical Name: 11-Chloro-5-(5-cyclopropyl-1,2,4-ox
Biological ActivityGABAA receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tang et al (1995) U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J.Pharmacol.Exp.Ther. 275 761. PMID: 7473164.
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Keywords: U 90042, supplier, GABAA, receptor, ligands, Receptors, U90042, Tocris Bioscience, GABAA Receptor Modulator products
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July 8 - 12, 2017