2-Furoyl-LIGRLO-amide

Cat. No. 3015

2-Furoyl-LIGRLO-amide 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2

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Biological Activity

Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Technical Data

M.Wt:
777.96
Formula:
C36H63N11O8
Sequence:
LIGRLX

(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
729589-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289. PMID: 17434682.

Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12. PMID: 15265236.

McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124. PMID: 14976230.

If you know of a relevant reference for 2-Furoyl-LIGRLO-amide please let us know.

Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346. PMID: 24469043.

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265. PMID: 23235155.

Do you know of a great paper that uses 2-Furoyl-LIGRLO-amide from Tocris? If so please let us know.

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Keywords: 2-Furoyl-LIGRLO-amide, supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Agonist products

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