Cat. No. 3015
Biological ActivityPotent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289. PMID: 17434682.
Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12. PMID: 15265236.
McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124. PMID: 14976230.
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Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265. PMID: 23235155.
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Keywords: 2-Furoyl-LIGRLO-amide, supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Agonist products
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