HOE 140

Cat. No. 3014

HOE 140 D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg

Price and Availability

For HOE 140 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Icatibant

Biological Activity

Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).

Technical Data

M.Wt:
1304.52
Formula:
C59H89N19O13S
Sequence:
RRPXGXSXXR

(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
130308-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108. PMID: 17026984.

Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683. PMID: 8075888.

Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769. PMID: 1364851.

If you know of a relevant reference for HOE 140 please let us know.

Citations are publications that use Tocris products. Selected citations for HOE 140 include:

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105. PMID: 27676088.

Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229. PMID: 26124706.

Do you know of a great paper that uses HOE 140 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: HOE 140, supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Tocris Bioscience, Bradykinin Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area

Retrobradykinin

Reverse analog of Bradykinin

TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

ML 233

Non-peptide apelin receptor agonist

BML 111

FPR2 (lipoxin A4 receptor) agonist

Amylin (rat)

Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Calcitonin (human)

Endogenous calcitonin receptor agonist; inhibits bone resorption

Spexin

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

MM 54

Potent apelin receptor antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.