Cat. No. 3014
Alternative Name: Icatibant
Biological ActivityPotent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108. PMID: 17026984.
Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683. PMID: 8075888.
Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769. PMID: 1364851.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for HOE 140 include:
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105. PMID: 27676088.
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229. PMID: 26124706.
Do you know of a great paper that uses HOE 140 from Tocris? If so please let us know.
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Keywords: HOE 140, supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Tocris Bioscience, Bradykinin Receptor Antagonist products
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