Cat. No. 2936
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)meth
Biological ActivityPotent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223.
Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759. PMID: 16789731.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NSC 66811 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NSC 66811, supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
Find multiple products by catalog number
April 10 - 13, 2017