Cat. No. 2936
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)meth
Biological ActivityPotent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223.
Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759. PMID: 16789731.
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Keywords: NSC 66811, supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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