CyPPA

Cat. No. 2953

CyPPA C16H23N5 [73029-73-9]

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Chemical Name: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

Biological Activity

Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.

Technical Data

M.Wt:
285.39
Formula:
C16H23N5
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
73029-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655. PMID: 17486140.

If you know of a relevant reference for CyPPA please let us know.

Citations are publications that use Tocris products. Selected citations for CyPPA include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177. PMID: 26454020.

Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528. PMID: 23446695.

Do you know of a great paper that uses CyPPA from Tocris? If so please let us know.

Keywords: CyPPA, supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products

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