[Des-octanoyl]-Ghrelin (rat)

Cat. No. 2951

[des-octanoyl]-Ghrelin (rat) Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg

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Alternative Name: Des-acyl ghrelin (rat)

Biological Activity

Non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release.

Technical Data

M.Wt:
3188.63
Formula:
C139H231N45O41
Sequence:
GSSFLSPEHQKAQQRKESKKPPAKLQPR
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
307950-60-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173. PMID: 14763915.

Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor Endocrinology 145 234. PMID: 14551228.

Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87. PMID: 12969753.

If you know of a relevant reference for [Des-octanoyl]-Ghrelin (rat) please let us know.

Citations are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (rat) include:

Engel et al (2015) Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl) 232 4285. PMID: 26319159.

Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. Br J Pharmacol 57 633. PMID: 21220707.

Do you know of a great paper that uses [Des-octanoyl]-Ghrelin (rat) from Tocris? If so please let us know.

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Keywords: [des-octanoyl]-Ghrelin (rat), supplier, circulating, ghrelin, devoid, activity, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, Receptor, 1a, Ghrelin, Tocris Bioscience, Ghrelin Receptor products

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