Cat. No. 2957
Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperid
Biological ActivityPotent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ross (2007) Allosterism and the cannabinoid CB1 receptors: the shape of things to come. Trends Pharmacol.Sci. 28 567. PMID: 18029031.
Price et al (2005) Allosteric modulation of the Cannabinoid CB1 receptor. Mol.Pharmacol. 68 1484. PMID: 16113085.
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Citations are publications that use Tocris products. Selected citations for Org 27569 include:
Baillie et al (2013) CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol 83 322. PMID: 23160940.
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Keywords: Org 27569, supplier, Potent, allosteric, CB1, modulators, cannabinoids, Receptors, Org27569, cb1r, Tocris Bioscience, CB1 Receptor Modulator products