B-HT 933 dihydrochloride

Cat. No. 2758

B-HT 933 dihydrochloride C9H15N3O.2HCl [36067-72-8]

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Alternative Name: Azepexole

Chemical Name: 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride

Biological Activity

Selective α2-adrenoceptor agonist. Exhibits greater than 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor.

Technical Data

M.Wt:
254.16
Formula:
C9H15N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
36067-72-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Parkinson and Hughes (1995) The mechanism of action of α2-adrenoceptors in human isolated subcutaneous resistance arteries. Br.J.Pharmacol. 115 1463. PMID: 8564206.

Bill et al (1989) The thermogenic actions of α2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic α2-adrenoceptor mechanism. Br.J.Pharmacol. 96 133. PMID: 2564288.

Kobinger and Pichler (1977) Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type". Naunyn-Schmied.Arch.Pharmacol. 300 39.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for B-HT 933 dihydrochloride include:

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Toxins (Basel) 32 14489. PMID: 23077035.

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Keywords: B-HT 933 dihydrochloride, supplier, B-HT933, dihydrochloride, azepexole, alpha2, α2, a2, adrenoceptors, agonists, selective, adrenergic, receptors, Tocris Bioscience, Adrenergic α2 Receptor Agonist products

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