NS 1738

Cat. No. 2995

NS 1738 C14H9Cl2F3N2O2 [501684-93-1]

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Chemical Name: N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea

Biological Activity

Selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.

Technical Data

M.Wt:
365.13
Formula:
C14H9Cl2F3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
501684-93-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Freitas et al (2013) The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J.Pharmacol.Exp.Ther. 344 264. PMID: 23115222.

Timmermann et al (2007) An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 323 294. PMID: 17625074.

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Keywords: NS 1738, supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, active, vivo, Nicotinic, Receptors, Acetylcholine, NS1738, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products

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