Cat. No. 2995
Chemical Name: N-(5-Chloro-2-hydroxyphenyl)-N'-[2-c
Biological ActivitySelective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Freitas et al (2013) The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J.Pharmacol.Exp.Ther. 344 264. PMID: 23115222.
Timmermann et al (2007) An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 323 294. PMID: 17625074.
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Citations are publications that use Tocris products. Selected citations for NS 1738 include:
Chatzidaki et al (2015) Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. Neuropharmacology 10 e0125116. PMID: 25906356.
Chatzidaki et al (2015) The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors. Int J Oncol 97 75. PMID: 25998276.
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Keywords: NS 1738, supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, active, vivo, Nicotinic, Receptors, Acetylcholine, NS1738, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products
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